CDKN2B-AS1 (Entrez ID: 100048912)

Entrez Gene ID 100048912
Official Gene Symbol CDKN2B-AS1 (GeneCards)
Full name CDKN2B antisense RNA 1
Location 9p21.3
Other ids MIM : 613149
HGNC : HGNC:34341
Ensembl : ENSG00000240498
Other names ANRIL, p15AS, PCAT12, CDKN2BAS, CDKN2B-AS, NCRNA00089
Summary This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]

Variants

Found 9 variants in this database.