| Entrez Gene ID | 10457 |
|---|---|
| Official Gene Symbol | GPNMB (GeneCards) |
| Full name | glycoprotein nmb |
| Location | 7p15.3 |
| Other ids | Vega : OTTHUMG00000022811 MIM : 604368 HGNC : HGNC:4462 Ensembl : ENSG00000136235 |
| Other names | NMB, HGFIN, PLCA3 |
| Summary | The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Found 3 variants in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 11010 | 10457 | GPNMB | 7 | 23306417 | 23306417 | Asymptomatic | HiSeq X Ten |
| 29231 | 10457 | GPNMB | 7 | 23296615 | 23296615 | Autism Spectrum Disorders | HiSeq X Ten PASM |
| 29800 | 10457 | GPNMB | 7 | 23296615 | 23296615 | Autism Spectrum Disorders | HiSeq X Ten PASM NextSeq500 |