SEMA3C (Entrez ID: 10512)

Entrez Gene ID 10512
Official Gene Symbol SEMA3C (GeneCards)
Full name semaphorin 3C
Location 7q21.11
Other ids Vega : OTTHUMG00000023447
MIM : 602645
HGNC : HGNC:10725
Ensembl : ENSG00000075223
Other names SemE, SEMAE
Summary This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]

Variants

Found 8 variants in this database.