ADAMTS5 (Entrez ID: 11096)

Entrez Gene ID 11096
Official Gene Symbol ADAMTS5 (GeneCards)
Full name ADAM metallopeptidase with thrombospondin type 1 motif 5
Location 21q21.3
Other ids Vega : OTTHUMG00000078686
MIM : 605007
HGNC : HGNC:221
Ensembl : ENSG00000154736
Other names ADMP-2, ADAM-TS5, ADAMTS-5, ADAMTS11, ADAM-TS5, ADAMTS-11, ADAM-TS11
Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]

Variants

Found 11 variants in this database.