POU6F2 (Entrez ID: 11281)

Entrez Gene ID 11281
Official Gene Symbol POU6F2 (GeneCards)
Full name POU class 6 homeobox 2
Location 7p14.1
Other ids Vega : OTTHUMG00000150803
MIM : 609062
HGNC : HGNC:21694
Ensembl : ENSG00000106536
Other names WT5, WTSL, RPF-1
Summary This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Variants

Found 11 variants in this database.