| Entrez Gene ID | 140883 |
|---|---|
| Official Gene Symbol | ZNF280B (GeneCards) |
| Full name | zinc finger protein 280B |
| Location | 22q11.22 |
| Other ids | Vega : OTTHUMG00000151066 HGNC : HGNC:23022 Ensembl : ENSG00000275004 |
| Other names | SUHW2, ZNF279, ZNF632, "5OY11.1", D87009.C22.3 |
| Summary | The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015] |
Found 1 variant in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 29600 | 140883 | ZNF280B | 22 | 22843578 | 22843578 | Autism Spectrum Disorders | MiSeq |