| Entrez Gene ID |
147945 |
| Official Gene Symbol |
NLRP4 (GeneCards) |
| Full name |
NLR family pyrin domain containing 4 |
| Location |
19q13.43 |
| Other ids |
Vega : OTTHUMG00000181734
MIM : 609645
HGNC : HGNC:22943
Ensembl : ENSG00000160505
|
| Other names |
CT58,
PAN2,
RNH2,
NALP4,
PYPAF4,
CLR19.5
|
| Summary |
The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016] |