DCC (Entrez ID: 1630)

Entrez Gene ID	1630
Official Gene Symbol	DCC (GeneCards)
Full name	DCC netrin 1 receptor
Location	18q21.2
Other ids	Vega : OTTHUMG00000132698 MIM : 120470 HGNC : HGNC:2701 Ensembl : ENSG00000187323
Other names	CRC18, CRCR1, MRMV1, HGPPS2, IGDCC1, NTN1R1
Summary	This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

Variants

Found 20 variants in this database.

Variant ID	Entrez Gene ID	Gene	Chromsome	Start	End	Disease	Method
20249	1630	DCC	18	50625943	50625943	Asymptomatic	HiSeq X Ten
20266	1630	DCC	18	50201897	50201897	Asymptomatic	HiSeq X Ten
20313	1630	DCC	18	50431891	50431891	Asymptomatic	HiSeq X Ten
20385	1630	DCC	18	51071730	51071730	Asymptomatic	HiSeq X Ten
20394	1630	DCC	18	50157476	50157476	Asymptomatic	HiSeq X Ten
20509	1630	DCC	18	50148615	50148615	Asymptomatic	HiSeq X Ten
20517	1630	DCC	18	50067339	50067339	Asymptomatic	HiSeq X Ten
20553	1630	DCC	18	50792826	50792826	Asymptomatic	HiSeq X Ten
20592	1630	DCC	18	50508650	50508650	Asymptomatic	HiSeq X Ten
20619	1630	DCC	18	50337854	50337854	Asymptomatic	HiSeq X Ten
20620	1630	DCC	18	50828925	50828925	Asymptomatic	HiSeq X Ten
20710	1630	DCC	18	50303385	50303385	Cockayne syndrome	HiSeq X Ten
20719	1630	DCC	18	50623976	50623976	Cockayne syndrome	HiSeq X Ten
20771	1630	DCC	18	50026713	50026713	Xeroderma Pigmentosum	HiSeq X Ten
20779	1630	DCC	18	50097676	50097676	Xeroderma Pigmentosum	HiSeq X Ten
20798	1630	DCC	18	50053251	50053251	Xeroderma Pigmentosum	HiSeq X Ten
23954	1630	DCC	18	50969971	50969971	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
23982	1630	DCC	18	50864030	50864030	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
23988	1630	DCC	18	50563239	50563239	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
28414	1630	DCC	18	50876781	50876781	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning