DCN (Entrez ID: 1634)

Entrez Gene ID 1634
Official Gene Symbol DCN (GeneCards)
Full name decorin
Location 12q21.33
Other ids Vega : OTTHUMG00000169998
MIM : 125255
HGNC : HGNC:2705
Ensembl : ENSG00000011465
Other names CSCD, PG40, PGII, PGS2, DSPG2, SLRR1B
Summary This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

Variants

Found 10 variants in this database.