Entrez Gene ID | 1634 |
---|---|
Official Gene Symbol | DCN (GeneCards) |
Full name | decorin |
Location | 12q21.33 |
Other ids | Vega : OTTHUMG00000169998 MIM : 125255 HGNC : HGNC:2705 Ensembl : ENSG00000011465 |
Other names | CSCD, PG40, PGII, PGS2, DSPG2, SLRR1B |
Summary | This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015] |
Found 10 variants in this database.
Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
---|---|---|---|---|---|---|---|
16060 | 1634 | DCN | 12 | 92207926 | 92207926 | Asymptomatic | HiSeq X Ten |
16149 | 1634 | DCN | 12 | 92187572 | 92187572 | Asymptomatic | HiSeq X Ten HiSeq 2000 |
16187 | 1634 | DCN | 12 | 92187572 | 92187572 | Asymptomatic | HiSeq X Ten HiSeq 2000 |
16227 | 1634 | DCN | 12 | 91701789 | 91701789 | Asymptomatic | HiSeq X Ten HiSeq 2000 |
16301 | 1634 | DCN | 12 | 91658887 | 91658887 | Asymptomatic | HiSeq X Ten HiSeq 2000 |
16924 | 1634 | DCN | 12 | 91704423 | 91704423 | Cockayne syndrome | HiSeq X Ten HiSeq 2000 |
16961 | 1634 | DCN | 12 | 91960849 | 91960849 | Cockayne syndrome | HiSeq X Ten HiSeq 2000 |
17031 | 1634 | DCN | 12 | 92043747 | 92043747 | Xeroderma Pigmentosum | HiSeq X Ten HiSeq 2000 |
23677 | 1634 | DCN | 12 | 92239235 | 92239235 | Asymptomatic | HiSeq X Ten HiSeq 2000 Single cell Sequencing Cell cloning |
29177 | 1634 | DCN | 12 | 91558512 | 91558512 | Autism Spectrum Disorders | HiSeq X Ten HiSeq 2000 Single cell Sequencing Cell cloning PASM |