| Entrez Gene ID |
1952 |
| Official Gene Symbol |
CELSR2 (GeneCards) |
| Full name |
cadherin EGF LAG seven-pass G-type receptor 2 |
| Location |
1p13.3 |
| Other ids |
Vega : OTTHUMG00000012003
MIM : 604265
HGNC : HGNC:3231
Ensembl : ENSG00000143126
|
| Other names |
EGFL2,
MEGF3,
ADGRC2,
CDHF10,
Flamingo1
|
| Summary |
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008] |