| Entrez Gene ID |
1978 |
| Official Gene Symbol |
EIF4EBP1 (GeneCards) |
| Full name |
eukaryotic translation initiation factor 4E binding protein 1 |
| Location |
8p11.23 |
| Other ids |
Vega : OTTHUMG00000164012
MIM : 602223
HGNC : HGNC:3288
Ensembl : ENSG00000187840
|
| Other names |
BP-1,
4EBP1,
4E-BP1,
PHAS-I
|
| Summary |
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008] |