Entrez Gene ID	2066
Official Gene Symbol	ERBB4 (GeneCards)
Full name	erb-b2 receptor tyrosine kinase 4
Location	2q34
Other ids	Vega : OTTHUMG00000133012 MIM : 600543 HGNC : HGNC:3432 Ensembl : ENSG00000178568
Other names	HER4, ALS19, p180erbB4
Summary	This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Variants

Found 115 variants in this database.

Variant ID	Entrez Gene ID	Gene	Chromsome	Start	End	Disease	Method
3126	2066	ERBB4	2	213289913	213289913	Asymptomatic	HiSeq X Ten
3186	2066	ERBB4	2	213679114	213679114	Asymptomatic	HiSeq X Ten
3612	2066	ERBB4	2	212845562	212845562		HiSeq X Ten
3789	2066	ERBB4	2	212835294	212835294	Asymptomatic	HiSeq X Ten
3809	2066	ERBB4	2	213502641	213502641	Asymptomatic	HiSeq X Ten
3827	2066	ERBB4	2	213563527	213563527	Asymptomatic	HiSeq X Ten
3889	2066	ERBB4	2	212456912	212456912	Asymptomatic	HiSeq X Ten
3890	2066	ERBB4	2	212908310	212908310	Asymptomatic	HiSeq X Ten
3928	2066	ERBB4	2	213211513	213211513	Asymptomatic	HiSeq X Ten
3997	2066	ERBB4	2	212576705	212576705	Asymptomatic	HiSeq X Ten
4015	2066	ERBB4	2	212866775	212866775	Asymptomatic	HiSeq X Ten
4238	2066	ERBB4	2	213214463	213214463	Asymptomatic	HiSeq X Ten
4397	2066	ERBB4	2	212409183	212409183	Cockayne syndrome	HiSeq X Ten
4402	2066	ERBB4	2	213637008	213637008	Cockayne syndrome	HiSeq X Ten
4455	2066	ERBB4	2	213211066	213211066	Xeroderma Pigmentosum	HiSeq X Ten
4543	2066	ERBB4	2	212783730	212783730	Xeroderma Pigmentosum	HiSeq X Ten
22572	2066	ERBB4	2	213473433	213473433	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
22682	2066	ERBB4	2	212834736	212834736	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
24654	2066	ERBB4	2	213787395	213787395	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
24706	2066	ERBB4	2	212494432	212494432	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
24745	2066	ERBB4	2	212887173	212887173	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
24761	2066	ERBB4	2	212419661	212419661	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
24799	2066	ERBB4	2	212494432	212494432	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
24838	2066	ERBB4	2	212494432	212494432	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
24862	2066	ERBB4	2	212494432	212494432	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
24893	2066	ERBB4	2	213155077	213155077	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning
31019	2066	ERBB4	2	212652844	212652844	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31020	2066	ERBB4	2	212248617	212248617	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31021	2066	ERBB4	2	212286828	212286828	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31022	2066	ERBB4	2	212570076	212570076	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31023	2066	ERBB4	2	212576809	212576809	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31024	2066	ERBB4	2	212248354	212248354	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31025	2066	ERBB4	2	212286828	212286828	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31026	2066	ERBB4	2	212426679	212426679	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31027	2066	ERBB4	2	212483982	212483982	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31028	2066	ERBB4	2	212426679	212426679	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31029	2066	ERBB4	2	212483982	212483982	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31030	2066	ERBB4	2	212286764	212286764	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31031	2066	ERBB4	2	212248422	212248422	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31032	2066	ERBB4	2	212248710	212248710	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31033	2066	ERBB4	2	212488680	212488680	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31034	2066	ERBB4	2	212576831	212576831	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31035	2066	ERBB4	2	212248617	212248617	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31036	2066	ERBB4	2	212295747	212295747	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31037	2066	ERBB4	2	212426650	212426650	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31038	2066	ERBB4	2	212570080	212570080	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31039	2066	ERBB4	2	212248587	212248587	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31040	2066	ERBB4	2	212488718	212488718	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31041	2066	ERBB4	2	212248450	212248450	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
31042	2066	ERBB4	2	212989517	212989517	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32369	2066	ERBB4	2	212495246	212495246	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32370	2066	ERBB4	2	212426688	212426688	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32371	2066	ERBB4	2	212251870	212251870	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32372	2066	ERBB4	2	212495246	212495246	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32373	2066	ERBB4	2	212426688	212426688	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32374	2066	ERBB4	2	212248491	212248491	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32375	2066	ERBB4	2	212248688	212248688	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32376	2066	ERBB4	2	212285277	212285277	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32377	2066	ERBB4	2	212286810	212286810	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32378	2066	ERBB4	2	212484001	212484001	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32379	2066	ERBB4	2	212248383	212248383	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32380	2066	ERBB4	2	212251766	212251766	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32381	2066	ERBB4	2	212295810	212295810	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32382	2066	ERBB4	2	212295824	212295824	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32383	2066	ERBB4	2	212251874	212251874	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32384	2066	ERBB4	2	212288918	212288918	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32385	2066	ERBB4	2	212293140	212293140	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32386	2066	ERBB4	2	212537939	212537939	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32387	2066	ERBB4	2	212587204	212587204	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32388	2066	ERBB4	2	212252680	212252680	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32389	2066	ERBB4	2	212248370	212248370	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32390	2066	ERBB4	2	212543911	212543911	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32391	2066	ERBB4	2	212289018	212289018	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32392	2066	ERBB4	2	212251707	212251707	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32393	2066	ERBB4	2	212285194	212285194	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32394	2066	ERBB4	2	212522529	212522529	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32395	2066	ERBB4	2	212488710	212488710	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32396	2066	ERBB4	2	212570071	212570071	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32397	2066	ERBB4	2	212570071	212570071	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32398	2066	ERBB4	2	212288974	212288974	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32399	2066	ERBB4	2	212570059	212570059	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32400	2066	ERBB4	2	212570044	212570044	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32401	2066	ERBB4	2	212570044	212570044	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32402	2066	ERBB4	2	212251642	212251642	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32403	2066	ERBB4	2	212248631	212248631	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32404	2066	ERBB4	2	212587175	212587175	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32405	2066	ERBB4	2	212578285	212578285	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32406	2066	ERBB4	2	212285172	212285172	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32407	2066	ERBB4	2	212495242	212495242	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32408	2066	ERBB4	2	212587245	212587245	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32409	2066	ERBB4	2	212488744	212488744	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32410	2066	ERBB4	2	212566819	212566819	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
32411	2066	ERBB4	2	212295786	212295786	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33637	2066	ERBB4	2	212495185	212495185	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33638	2066	ERBB4	2	212495185	212495185	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33639	2066	ERBB4	2	212522546	212522546	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33640	2066	ERBB4	2	212248765	212248765	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33641	2066	ERBB4	2	212426743	212426743	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33642	2066	ERBB4	2	212530073	212530073	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33643	2066	ERBB4	2	212530073	212530073	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33644	2066	ERBB4	2	212495285	212495285	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33645	2066	ERBB4	2	212615376	212615376	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33646	2066	ERBB4	2	212652804	212652804	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33647	2066	ERBB4	2	212615376	212615376	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33648	2066	ERBB4	2	212248462	212248462	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33649	2066	ERBB4	2	212812241	212812241	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33650	2066	ERBB4	2	212495213	212495213	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33651	2066	ERBB4	2	212566818	212566818	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33652	2066	ERBB4	2	212488718	212488718	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33653	2066	ERBB4	2	212248758	212248758	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
33654	2066	ERBB4	2	212578321	212578321	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
34141	2066	ERBB4	2	212570084	212570085	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
34142	2066	ERBB4	2	212989526	212989526	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
34143	2066	ERBB4	2	212652795	212652795	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel
34144	2066	ERBB4	2	212248535	212248535	Asymptomatic	HiSeq X Ten Single cell Sequencing Cell cloning NGS gene panel

ERBB4 (Entrez ID: 2066)

Variants