MECOM (Entrez ID: 2122)

Entrez Gene ID 2122
Official Gene Symbol MECOM (GeneCards)
Full name MDS1 and EVI1 complex locus
Location 3q26.2
Other ids Vega : OTTHUMG00000158596
MIM : 165215
HGNC : HGNC:3498
Ensembl : ENSG00000085276
Other names EVI1, MDS1, KMT8E, PRDM3, RUSAT2, MDS1-EVI1, AML1-EVI-1
Summary The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Variants

Found 8 variants in this database.