DAAM1 (Entrez ID: 23002)

Entrez Gene ID 23002
Official Gene Symbol DAAM1 (GeneCards)
Full name dishevelled associated activator of morphogenesis 1
Location 14q23.1
Other ids Vega : OTTHUMG00000140326
MIM : 606626
HGNC : HGNC:18142
Ensembl : ENSG00000100592
Other names None
Summary Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]

Variants

Found 7 variants in this database.