| Entrez Gene ID |
23092 |
| Official Gene Symbol |
ARHGAP26 (GeneCards) |
| Full name |
Rho GTPase activating protein 26 |
| Location |
5q31.3 |
| Other ids |
Vega : OTTHUMG00000059705
MIM : 605370
HGNC : HGNC:17073
Ensembl : ENSG00000145819
|
| Other names |
GRAF,
GRAF1,
OPHN1L,
OPHN1L1
|
| Summary |
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017] |