| Entrez Gene ID |
23513 |
| Official Gene Symbol |
SCRIB (GeneCards) |
| Full name |
scribbled planar cell polarity protein |
| Location |
8q24.3 |
| Other ids |
Vega : OTTHUMG00000165154
MIM : 607733
HGNC : HGNC:30377
Ensembl : ENSG00000180900
|
| Other names |
CRIB1,
SCRB1,
SCRIB1,
Vartl
|
| Summary |
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |