| Entrez Gene ID |
2547 |
| Official Gene Symbol |
XRCC6 (GeneCards) |
| Full name |
X-ray repair cross complementing 6 |
| Location |
22q13.2 |
| Other ids |
Vega : OTTHUMG00000151190
MIM : 152690
HGNC : HGNC:4055
Ensembl : ENSG00000196419
|
| Other names |
ML8,
KU70,
TLAA,
CTC75,
CTCBF,
G22P1
|
| Summary |
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008] |