| Entrez Gene ID | 26574 |
|---|---|
| Official Gene Symbol | AATF (GeneCards) |
| Full name | apoptosis antagonizing transcription factor |
| Location | 17q12 |
| Other ids | Vega : OTTHUMG00000188458 MIM : 608463 HGNC : HGNC:19235 Ensembl : ENSG00000275700 |
| Other names | DED, BFR2, CHE1, CHE-1 |
| Summary | The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008] |
Found 2 variants in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 20118 | 26574 | AATF | 17 | 35434937 | 35434937 | Cockayne syndrome | HiSeq X Ten |
| 29902 | 26574 | AATF | 17 | 35413915 | 35413915 | Autism Spectrum Disorders | HiSeq X Ten NextSeq500 |