| Entrez Gene ID |
26986 |
| Official Gene Symbol |
PABPC1 (GeneCards) |
| Full name |
poly(A) binding protein cytoplasmic 1 |
| Location |
8q22.3 |
| Other ids |
Vega : OTTHUMG00000164779
MIM : 604679
HGNC : HGNC:8554
Ensembl : ENSG00000070756
|
| Other names |
PAB1,
PABP,
PABP1,
PABPC2,
PABPL1
|
| Summary |
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010] |