| Entrez Gene ID |
28234 |
| Official Gene Symbol |
SLCO1B3 (GeneCards) |
| Full name |
solute carrier organic anion transporter family member 1B3 |
| Location |
12p12.2 |
| Other ids |
Vega : OTTHUMG00000169011
MIM : 605495
HGNC : HGNC:10961
Ensembl : ENSG00000111700
|
| Other names |
LST3,
HBLRR,
LST-2,
OATP8,
OATP-8,
OATP1B3,
SLC21A8,
LST-3TM13
|
| Summary |
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017] |