| Entrez Gene ID |
3697 |
| Official Gene Symbol |
ITIH1 (GeneCards) |
| Full name |
inter-alpha-trypsin inhibitor heavy chain 1 |
| Location |
3p21.1 |
| Other ids |
Vega : OTTHUMG00000150312
MIM : 147270
HGNC : HGNC:6166
Ensembl : ENSG00000055957
|
| Other names |
H1P,
ITIH,
SHAP,
IATIH,
IGHEP1,
ITI-HC1
|
| Summary |
This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015] |