JARID2 (Entrez ID: 3720)

Entrez Gene ID 3720
Official Gene Symbol JARID2 (GeneCards)
Full name jumonji and AT-rich interaction domain containing 2
Location 6p22.3
Other ids Vega : OTTHUMG00000014293
MIM : 601594
HGNC : HGNC:6196
Ensembl : ENSG00000008083
Other names JMJ
Summary This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]

Variants

Found 4 variants in this database.