KCNJ3 (Entrez ID: 3760)

Entrez Gene ID 3760
Official Gene Symbol KCNJ3 (GeneCards)
Full name potassium voltage-gated channel subfamily J member 3
Location 2q24.1
Other ids Vega : OTTHUMG00000131937
MIM : 601534
HGNC : HGNC:6264
Ensembl : ENSG00000162989
Other names KGA, GIRK1, KIR3.1
Summary Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]

Variants

Found 19 variants in this database.