| Entrez Gene ID | 3845 |
|---|---|
| Official Gene Symbol | KRAS (GeneCards) |
| Full name | KRAS proto-oncogene, GTPase |
| Location | 12p12.1 |
| Other ids | Vega : OTTHUMG00000171193 MIM : 190070 HGNC : HGNC:6407 Ensembl : ENSG00000133703 |
| Other names | NS, NS3, CFC2, RALD, K-Ras, KRAS1, KRAS2, RASK2, KI-RAS, C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, c-Ki-ras2 |
| Summary | This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008] |
Found 20 variants in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 609 | 3845 | KRAS | 12 | 25398284 | 25398284 | Linear nevus sebaceous syndrome | Life Ion |
| 1412 | 3845 | KRAS | 12 | 25380275 | 25380275 | Melorheostosis | Life Ion HiSeq 2000 |
| 1413 | 3845 | KRAS | 12 | 25398284 | 25398284 | Arteriovenous Malformations of the Brain | Life Ion HiSeq 2000 NA |
| 1414 | 3845 | KRAS | 12 | 25398284 | 25398284 | Arteriovenous Malformations of the Brain | Life Ion HiSeq 2000 NA |
| 1415 | 3845 | KRAS | 12 | 25398284 | 25398284 | Arteriovenous Malformations of the Brain | Life Ion HiSeq 2000 NA |
| 16312 | 3845 | KRAS | 12 | 25510857 | 25510857 | Asymptomatic | Life Ion HiSeq 2000 NA HiSeq X Ten |
| 30423 | 3845 | KRAS | 12 | 25398281 | 25398281 | Asymptomatic | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP |
| 30424 | 3845 | KRAS | 12 | 25398281 | 25398281 | Asymptomatic | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP |
| 30425 | 3845 | KRAS | 12 | 25398281 | 25398281 | Asymptomatic | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP |
| 30467 | 3845 | KRAS | 12 | 25378561 | 25378561 | Oculo ectodermal syndrome | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger |
| 30468 | 3845 | KRAS | 12 | 25378561 | 25378561 | Oculo ectodermal syndrome | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger |
| 30469 | 3845 | KRAS | 12 | 25378562 | 25378562 | Oculo ectodermal syndrome | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger |
| 30470 | 3845 | KRAS | 12 | 25378562 | 25378562 | Oculo ectodermal syndrome | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger |
| 30541 | 3845 | KRAS | 12 | 25380235 | 25380235 | Asymptomatic | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger NGS gene panel |
| 31452 | 3845 | KRAS | 12 | 25398284 | 25398284 | Asymptomatic | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger NGS gene panel |
| 31453 | 3845 | KRAS | 12 | 25368408 | 25368408 | Asymptomatic | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger NGS gene panel |
| 33110 | 3845 | KRAS | 12 | 25398284 | 25398284 | Asymptomatic | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger NGS gene panel |
| 34029 | 3845 | KRAS | 12 | 25380185 | 25380185 | Asymptomatic | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger NGS gene panel |
| 34633 | 3845 | KRAS | 12 | 25398281 | 25398281 | Oculo ectodermal syndrome | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger NGS gene panel Whole Genome Sequencing Ion Torrent PGM Sequencing |
| 34634 | 3845 | KRAS | 12 | 25398262 | 25398262 | Oculo ectodermal syndrome | Life Ion HiSeq 2000 NA HiSeq X Ten smMIP Sanger NGS gene panel Whole Genome Sequencing Ion Torrent PGM Sequencing Sanger Sequencing Ion Torrent Ampliseq |