LAMA2 (Entrez ID: 3908)

Entrez Gene ID 3908
Official Gene Symbol LAMA2 (GeneCards)
Full name laminin subunit alpha 2
Location 6q22.33
Other ids Vega : OTTHUMG00000015545
MIM : 156225
HGNC : HGNC:6482
Ensembl : ENSG00000196569
Other names LAMM
Summary Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Variants

Found 11 variants in this database.