LPA (Entrez ID: 4018)

Entrez Gene ID 4018
Official Gene Symbol LPA (GeneCards)
Full name lipoprotein(a)
Location 6q25.3-q26
Other ids Vega : OTTHUMG00000015956
MIM : 152200
HGNC : HGNC:6667
Ensembl : ENSG00000198670
Other names LP, AK38, APOA
Summary The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

Variants

Found 5 variants in this database.