| Entrez Gene ID | 4301 |
|---|---|
| Official Gene Symbol | AFDN (GeneCards) |
| Full name | afadin, adherens junction formation factor |
| Location | 6q27 |
| Other ids | Vega : OTTHUMG00000016031 MIM : 159559 HGNC : HGNC:7137 Ensembl : ENSG00000130396 |
| Other names | AF6, MLLT4, MLL-AF6, l-afadin |
| Summary | This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011] |