| Entrez Gene ID | 4796 |
|---|---|
| Official Gene Symbol | TONSL (GeneCards) |
| Full name | tonsoku like, DNA repair protein |
| Location | 8q24.3 |
| Other ids | Vega : OTTHUMG00000153122 MIM : 604546 HGNC : HGNC:7801 Ensembl : ENSG00000160949 |
| Other names | IKBR, NFKBIL2 |
| Summary | The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008] |
Found 1 variant in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 1108 | 4796 | TONSL | 8 | 145664112 | 145664112 | Human Skin Fibroblasts | HiSeq 2500 |