WWOX (Entrez ID: 51741)

Entrez Gene ID	51741
Official Gene Symbol	WWOX (GeneCards)
Full name	WW domain containing oxidoreductase
Location	16q23.1-q23.2
Other ids	Vega : OTTHUMG00000176851 MIM : 605131 HGNC : HGNC:12799 Ensembl : ENSG00000186153
Other names	FOR, WOX1, EIEE28, FRA16D, SCAR12, HHCMA56, PRO0128, SDR41C1, D16S432E
Summary	This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Variants

Found 21 variants in this database.

Variant ID	Entrez Gene ID	Gene	Chromsome	Start	End	Disease	Method
19340	51741	WWOX	16	78201062	78201062	Asymptomatic	HiSeq X Ten
19367	51741	WWOX	16	78845812	78845812	Asymptomatic	HiSeq X Ten
19370	51741	WWOX	16	78860784	78860784	Asymptomatic	HiSeq X Ten HiSeq 2000
19390	51741	WWOX	16	79286116	79286116	Asymptomatic	HiSeq X Ten HiSeq 2000
19416	51741	WWOX	16	79309835	79309835	Asymptomatic	HiSeq X Ten HiSeq 2000
19426	51741	WWOX	16	79554047	79554047	Asymptomatic	HiSeq X Ten HiSeq 2000
19449	51741	WWOX	16	78978266	78978266	Asymptomatic	HiSeq X Ten HiSeq 2000
19463	51741	WWOX	16	78405392	78405392	Asymptomatic	HiSeq X Ten HiSeq 2000
19506	51741	WWOX	16	78858650	78858650	Asymptomatic	HiSeq X Ten HiSeq 2000
19568	51741	WWOX	16	78460767	78460767	Asymptomatic	HiSeq X Ten HiSeq 2000
19593	51741	WWOX	16	78521269	78521269	Asymptomatic	HiSeq X Ten HiSeq 2000
19609	51741	WWOX	16	78962596	78962596	Asymptomatic	HiSeq X Ten HiSeq 2000
19630	51741	WWOX	16	78403723	78403723	Asymptomatic	HiSeq X Ten HiSeq 2000
19643	51741	WWOX	16	78151104	78151104	Asymptomatic	HiSeq X Ten HiSeq 2000
19650	51741	WWOX	16	79463577	79463577	Asymptomatic	HiSeq X Ten HiSeq 2000
19688	51741	WWOX	16	79565533	79565533	Cockayne syndrome	HiSeq X Ten HiSeq 2000
19711	51741	WWOX	16	79004021	79004021	Cockayne syndrome	HiSeq X Ten HiSeq 2000
19754	51741	WWOX	16	78991472	78991472	Xeroderma Pigmentosum	HiSeq X Ten HiSeq 2000
23878	51741	WWOX	16	78418877	78418877	Asymptomatic	HiSeq X Ten HiSeq 2000 Single cell Sequencing Cell cloning
34560	51741	WWOX	16	78552769	78552769	Asymptomatic	HiSeq X Ten HiSeq 2000 Single cell Sequencing Cell cloning Whole Genome Sequencing Ion Torrent PGM Sequencing
34561	51741	WWOX	16	79069368	79069368	Asymptomatic	HiSeq X Ten HiSeq 2000 Single cell Sequencing Cell cloning Whole Genome Sequencing Ion Torrent PGM Sequencing