| Entrez Gene ID |
5295 |
| Official Gene Symbol |
PIK3R1 (GeneCards) |
| Full name |
phosphoinositide-3-kinase regulatory subunit 1 |
| Location |
5q13.1 |
| Other ids |
Vega : OTTHUMG00000131251
MIM : 171833
HGNC : HGNC:8979
Ensembl : ENSG00000145675
|
| Other names |
p85,
AGM7,
GRB1,
IMD36,
p85-ALPHA
|
| Summary |
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] |