| Entrez Gene ID | 5340 |
|---|---|
| Official Gene Symbol | PLG (GeneCards) |
| Full name | plasminogen |
| Location | 6q26 |
| Other ids | Vega : OTTHUMG00000015957 MIM : 173350 HGNC : HGNC:9071 Ensembl : ENSG00000122194 |
| Other names | None |
| Summary | The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] |