| Entrez Gene ID |
5434 |
| Official Gene Symbol |
POLR2E (GeneCards) |
| Full name |
RNA polymerase II subunit E |
| Location |
19p13.3 |
| Other ids |
Vega : OTTHUMG00000181873
MIM : 180664
HGNC : HGNC:9192
Ensembl : ENSG00000099817
|
| Other names |
RPB5,
XAP4,
RPABC1,
hRPB25,
hsRPB5
|
| Summary |
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] |