| Entrez Gene ID |
5511 |
| Official Gene Symbol |
PPP1R8 (GeneCards) |
| Full name |
protein phosphatase 1 regulatory subunit 8 |
| Location |
1p35.3 |
| Other ids |
Vega : OTTHUMG00000003734
MIM : 602636
HGNC : HGNC:9296
Ensembl : ENSG00000117751
|
| Other names |
ARD1,
ARD-1,
NIPP1,
NIPP-1,
PRO2047
|
| Summary |
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008] |