| Entrez Gene ID | 5602 |
|---|---|
| Official Gene Symbol | MAPK10 (GeneCards) |
| Full name | mitogen-activated protein kinase 10 |
| Location | 4q21.3 |
| Other ids | Vega : OTTHUMG00000130604 MIM : 602897 HGNC : HGNC:6872 Ensembl : ENSG00000109339 |
| Other names | JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK |
| Summary | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017] |
Found 11 variants in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 1450 | 5602 | MAPK10 | 4 | 86988964 | 86988964 | Multiple Sclerosis | sequencing |
| 6182 | 5602 | MAPK10 | 4 | 87389375 | 87389375 | Asymptomatic | sequencing HiSeq X Ten |
| 6260 | 5602 | MAPK10 | 4 | 87438819 | 87438819 | Asymptomatic | sequencing HiSeq X Ten |
| 6969 | 5602 | MAPK10 | 4 | 87434701 | 87434701 | Asymptomatic | sequencing HiSeq X Ten |
| 7256 | 5602 | MAPK10 | 4 | 87336491 | 87336491 | Cockayne syndrome | sequencing HiSeq X Ten |
| 7301 | 5602 | MAPK10 | 4 | 87152306 | 87152306 | Cockayne syndrome | sequencing HiSeq X Ten |
| 25406 | 5602 | MAPK10 | 4 | 87195279 | 87195279 | Asymptomatic | sequencing HiSeq X Ten Single cell Sequencing Cell cloning |
| 25487 | 5602 | MAPK10 | 4 | 87440935 | 87440935 | Asymptomatic | sequencing HiSeq X Ten Single cell Sequencing Cell cloning |
| 25524 | 5602 | MAPK10 | 4 | 87455908 | 87455908 | Asymptomatic | sequencing HiSeq X Ten Single cell Sequencing Cell cloning |
| 25668 | 5602 | MAPK10 | 4 | 86956173 | 86956173 | Asymptomatic | sequencing HiSeq X Ten Single cell Sequencing Cell cloning |
| 25727 | 5602 | MAPK10 | 4 | 86994725 | 86994725 | Asymptomatic | sequencing HiSeq X Ten Single cell Sequencing Cell cloning |