| Entrez Gene ID |
5714 |
| Official Gene Symbol |
PSMD8 (GeneCards) |
| Full name |
proteasome 26S subunit, non-ATPase 8 |
| Location |
19q13.2 |
| Other ids |
Vega : OTTHUMG00000150691
MIM : 617844
HGNC : HGNC:9566
Ensembl : ENSG00000099341
|
| Other names |
S14,
p31,
HIP6,
HYPF,
Nin1p,
Rpn12,
HEL-S-91n
|
| Summary |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008] |