PTPRM (Entrez ID: 5797)

Entrez Gene ID 5797
Official Gene Symbol PTPRM (GeneCards)
Full name protein tyrosine phosphatase, receptor type M
Location 18p11.23
Other ids Vega : OTTHUMG00000131575
MIM : 176888
HGNC : HGNC:9675
Ensembl : ENSG00000173482
Other names RPTPM, RPTPU, PTPRL1, hR-PTP, R-PTP-MU
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Variants

Found 12 variants in this database.