RAD51B (Entrez ID: 5890)

Entrez Gene ID 5890
Official Gene Symbol RAD51B (GeneCards)
Full name RAD51 paralog B
Location 14q24.1
Other ids Vega : OTTHUMG00000157530
MIM : 602948
HGNC : HGNC:9822
Ensembl : ENSG00000182185
Other names REC2, R51H2, RAD51L1
Summary The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]

Variants

Found 19 variants in this database.