| Entrez Gene ID | 64848 |
|---|---|
| Official Gene Symbol | YTHDC2 (GeneCards) |
| Full name | YTH domain containing 2 |
| Location | 5q22.2 |
| Other ids | Vega : OTTHUMG00000128837 MIM : 616530 HGNC : HGNC:24721 Ensembl : ENSG00000047188 |
| Other names | CAHL, hYTHDC2 |
| Summary | This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016] |
Found 11 variants in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 7550 | 64848 | YTHDC2 | 5 | 113332655 | 113332655 | Asymptomatic | HiSeq 2000 |
| 7759 | 64848 | YTHDC2 | 5 | 113019261 | 113019261 | Asymptomatic | HiSeq 2000 HiSeq X Ten |
| 7862 | 64848 | YTHDC2 | 5 | 113182179 | 113182179 | Asymptomatic | HiSeq 2000 HiSeq X Ten |
| 7921 | 64848 | YTHDC2 | 5 | 112944069 | 112944069 | Asymptomatic | HiSeq 2000 HiSeq X Ten |
| 8221 | 64848 | YTHDC2 | 5 | 113339769 | 113339769 | Asymptomatic | HiSeq 2000 HiSeq X Ten |
| 8594 | 64848 | YTHDC2 | 5 | 113337874 | 113337874 | Cockayne syndrome | HiSeq 2000 HiSeq X Ten |
| 8769 | 64848 | YTHDC2 | 5 | 113196973 | 113196973 | Cockayne syndrome | HiSeq 2000 HiSeq X Ten |
| 8833 | 64848 | YTHDC2 | 5 | 113056884 | 113056884 | Xeroderma Pigmentosum | HiSeq 2000 HiSeq X Ten |
| 8851 | 64848 | YTHDC2 | 5 | 113261525 | 113261525 | Xeroderma Pigmentosum | HiSeq 2000 HiSeq X Ten |
| 8869 | 64848 | YTHDC2 | 5 | 113173019 | 113173019 | Xeroderma Pigmentosum | HiSeq 2000 HiSeq X Ten |
| 26042 | 64848 | YTHDC2 | 5 | 113083089 | 113083089 | Asymptomatic | HiSeq 2000 HiSeq X Ten Single cell Sequencing Cell cloning |