| Entrez Gene ID | 6678 |
|---|---|
| Official Gene Symbol | SPARC (GeneCards) |
| Full name | secreted protein acidic and cysteine rich |
| Location | 5q33.1 |
| Other ids | Vega : OTTHUMG00000130122 MIM : 182120 HGNC : HGNC:11219 Ensembl : ENSG00000113140 |
| Other names | ON, OI17, BM-40 |
| Summary | This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015] |