MAP3K7 (Entrez ID: 6885)

Entrez Gene ID 6885
Official Gene Symbol MAP3K7 (GeneCards)
Full name mitogen-activated protein kinase kinase kinase 7
Location 6q15
Other ids Vega : OTTHUMG00000015217
MIM : 602614
HGNC : HGNC:6859
Ensembl : ENSG00000135341
Other names CSCF, FMD2, TAK1, MEKK7, TGF1a
Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Variants

Found 10 variants in this database.