TFAP2B (Entrez ID: 7021)

Entrez Gene ID 7021
Official Gene Symbol TFAP2B (GeneCards)
Full name transcription factor AP-2 beta
Location 6p12.3
Other ids Vega : OTTHUMG00000014836
MIM : 601601
HGNC : HGNC:11743
Ensembl : ENSG00000008196
Other names PDA2, AP-2B, AP2-B
Summary This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

Variants

Found 10 variants in this database.