| Entrez Gene ID |
7090 |
| Official Gene Symbol |
TLE3 (GeneCards) |
| Full name |
transducin like enhancer of split 3 |
| Location |
15q23 |
| Other ids |
Vega : OTTHUMG00000172121
MIM : 600190
HGNC : HGNC:11839
Ensembl : ENSG00000140332
|
| Other names |
ESG,
ESG3,
GRG3,
HsT18976
|
| Summary |
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] |