| Entrez Gene ID | 7113 |
|---|---|
| Official Gene Symbol | TMPRSS2 (GeneCards) |
| Full name | transmembrane serine protease 2 |
| Location | 21q22.3 |
| Other ids | Vega : OTTHUMG00000086762 MIM : 602060 HGNC : HGNC:11876 Ensembl : ENSG00000184012 |
| Other names | PP9284, PRSS10 |
| Summary | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
Found 6 variants in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 21577 | 7113 | TMPRSS2 | 21 | 43039844 | 43039844 | Asymptomatic | HiSeq X Ten |
| 21784 | 7113 | TMPRSS2 | 21 | 42838415 | 42838415 | Cockayne syndrome | HiSeq X Ten |
| 28639 | 7113 | TMPRSS2 | 21 | 42889834 | 42889834 | Asymptomatic | HiSeq X Ten Single cell Sequencing Cell cloning |
| 28650 | 7113 | TMPRSS2 | 21 | 42889834 | 42889834 | Asymptomatic | HiSeq X Ten Single cell Sequencing Cell cloning |
| 28666 | 7113 | TMPRSS2 | 21 | 42889834 | 42889834 | Asymptomatic | HiSeq X Ten Single cell Sequencing Cell cloning |
| 28704 | 7113 | TMPRSS2 | 21 | 43051618 | 43051618 | Asymptomatic | HiSeq X Ten Single cell Sequencing Cell cloning |