TSN (Entrez ID: 7247)

Entrez Gene ID 7247
Official Gene Symbol TSN (GeneCards)
Full name translin
Location 2q14.3
Other ids Vega : OTTHUMG00000153334
MIM : 600575
HGNC : HGNC:12379
Ensembl : ENSG00000211460
Other names C3PO, RCHF1, TBRBP, TRSLN, BCLF-1, REHF-1
Summary This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Variants

Found 24 variants in this database.