CALD1 (Entrez ID: 800)

Entrez Gene ID 800
Official Gene Symbol CALD1 (GeneCards)
Full name caldesmon 1
Location 7q33
Other ids Vega : OTTHUMG00000155407
MIM : 114213
HGNC : HGNC:1441
Ensembl : ENSG00000122786
Other names CDM, HCAD, LCAD, H-CAD, L-CAD, NAG22
Summary This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Variants

Found 3 variants in this database.