SEMA6D (Entrez ID: 80031)

Entrez Gene ID 80031
Official Gene Symbol SEMA6D (GeneCards)
Full name semaphorin 6D
Location 15q21.1
Other ids Vega : OTTHUMG00000172110
MIM : 609295
HGNC : HGNC:16770
Ensembl : ENSG00000137872
Other names None
Summary Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]

Variants

Found 17 variants in this database.