| Entrez Gene ID |
8554 |
| Official Gene Symbol |
PIAS1 (GeneCards) |
| Full name |
protein inhibitor of activated STAT 1 |
| Location |
15q23 |
| Other ids |
Vega : OTTHUMG00000172645
MIM : 603566
HGNC : HGNC:2752
Ensembl : ENSG00000033800
|
| Other names |
GBP,
ZMIZ3,
DDXBP1,
GU/RH-II
|
| Summary |
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |