CRADD (Entrez ID: 8738)

Entrez Gene ID 8738
Official Gene Symbol CRADD (GeneCards)
Full name CASP2 and RIPK1 domain containing adaptor with death domain
Location 12q22
Other ids Vega : OTTHUMG00000170322
MIM : 603454
HGNC : HGNC:2340
Ensembl : ENSG00000169372
Other names MRT34, RAIDD
Summary This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Variants

Found 7 variants in this database.