| Entrez Gene ID |
8778 |
| Official Gene Symbol |
SIGLEC5 (GeneCards) |
| Full name |
sialic acid binding Ig like lectin 5 |
| Location |
19q13.41 |
| Other ids |
Vega : OTTHUMG00000165510
MIM : 604200
HGNC : HGNC:10874
Ensembl : ENSG00000105501
|
| Other names |
CD170,
OBBP2,
CD33L2,
OB-BP2,
SIGLEC-5
|
| Summary |
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |