| Entrez Gene ID | 8826 |
|---|---|
| Official Gene Symbol | IQGAP1 (GeneCards) |
| Full name | IQ motif containing GTPase activating protein 1 |
| Location | 15q26.1 |
| Other ids | Vega : OTTHUMG00000149832 MIM : 603379 HGNC : HGNC:6110 Ensembl : ENSG00000140575 |
| Other names | SAR1, p195, HUMORFA01 |
| Summary | This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008] |
Found 3 variants in this database.
| Variant ID | Entrez Gene ID | Gene | Chromsome | Start | End | Disease | Method |
|---|---|---|---|---|---|---|---|
| 19251 | 8826 | IQGAP1 | 15 | 91045295 | 91045295 | Cockayne syndrome | HiSeq X Ten |
| 19318 | 8826 | IQGAP1 | 15 | 91054342 | 91054342 | Xeroderma Pigmentosum | HiSeq X Ten |
| 28029 | 8826 | IQGAP1 | 15 | 90983166 | 90983166 | Asymptomatic | HiSeq X Ten Single cell Sequencing Cell cloning |